A recent study suggests that people who stop using new GLP-1 drugs like Mounjaro or Wegovy can put back on reduced body mass much more quickly than those who stop traditional diet and exercise plans.
Findings released in a leading health publication shows that while overweight people can lose substantial amounts of their total mass while undergoing treatment, the mass is regained at an average rate of nearly a kilo each month after stopping.
"Individuals purchasing these medications must be informed of the danger of quick weight regain when the medication ends," stated expert Dr. Susan Jebb.
This pace of recovery means a return to starting mass within about a year and a half.
Analyzing Treatments
The study, which looked at 37 of studies involving thousands of patients, contrasted the results of these new drugs with older methods.
Scientists note that people who shed pounds through dieting usually see a more gradual creep back—perhaps 0.1 kg a month—once they finish.
Explaining the Rapid Regain
Nutrition scientists believe the way of the injections explains the amplified rebound.
GLP-1 drugs copy a natural hormone called GLP-1, which helps regulate hunger.
"Artificially providing GLP-1 concentrations far above than the body's typical production may cause the system to produce less of its endogenous GLP-1, and may also diminish sensitivity to its actions," said Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this GLP-1 'fix' leads to hunger is unsuppressed, making overeating a significant risk."
An Ongoing Issue?
Medical guidelines advise the jabs for people with obesity-related medical conditions, accompanied by recommended lifestyle changes.
A number of clinicians argue that, due to the likelihood of relapse, the therapy might need to be long-term.
This perspective is echoed by drug manufacturers, who note that the results "emphasize the persistent nature of obesity," akin to managing diseases like diabetes.
Patient Testimonies
Individuals who have stopped the medication report a sudden return of hunger.
"It felt as if a switch flipping and I was suddenly starving," said one woman.
The struggle is exacerbated if individuals have not developed sustainable dietary or behavioural modifications during treatment.
Growing Use
Recent estimates show that a significant number of people in the UK have used these injections in the last 12 months, with desire continuing to grow.
- Use is higher among women than males.
- The middle-aged age group shows the highest usage rates.
- Many obtain the drugs through private prescriptions rather than public health services.
In conclusion, experts caution that while these medications are powerful tools for shedding pounds, they are not a permanent solution and long-term success likely depends on combined lifestyle management.
